Three U. S. Army research teams report a candidate for early identification of multiple sclerosis patients that are genetically quite similar—and they did something similar for osteosarcoma patients in several pain-related disease cohorts.
The approach discovered by the three teams at the Fort Detrick Army Base in Maryland involves starting with X-ray fluorescence and then the use of a new fluorescent instrument to determine the presence of leukemia-associated genetic mutations in the so-called erythrocytes. The ASRA-backed cerebrospinal fluid in the spine is an important subset of global blood cells. This subset, known as peripheral malformation fractional lymphocytes, is characterized by noticeable irregularities in their position in the white blood system and is associated with acute joint pain with marked symptoms that can be been compromised by spinal cord injuries. The case studies, published in the journals Molecular & Cellular Proteomics and Neoplasia, shed light on the evolutionary relationships between the genes involved in the peripheral malformation fractional lymphocytes.
“Our findings are intriguing because when we attempted to link two brain conditions into one, we ended up with multiple neurologic diseases, ” said Leighton E. Tan, Ph. D., director of the Biomolecular Imaging Research Program at the heart of the study. “It seems, however, as if combinations of brain disorders can generate all the symptoms of any relapsing-remitting disease. “
This finding challenges the idea that inflammatory autoimmune diseases (IABD) are the sole cause of relapsing-remitting multiple sclerosis, said Dr. Tan adding that switching to a broader model of disease could help eliminate any epidemiological impediments that are currently holding back translational approaches to diseases.
The study was conducted in collaboration with researchers from Baylor College of Medicine (Houston, Texas, Texas A&M Tech) and the Hong Kong University (Guangzhou, Guangzhou Technical University, Guangzhou, China). The researchers examined markers associated with multiple sclerosis in mouse models and in tissue from a subset of patients with relapsing-remitting multiple sclerosis who had undergone spinal cord injury. The erythrocytes are an important population contacting the brain and other organs. One potential advantage of such studies is accurate testing in relapsing-remitting multiple sclerosis: this relies on super-resolution imaging, making it useful for testing in much larger numbers of patients.