According to investigators led by Mary-Ann Bjornsti.

When the group added topoisomerase I to the DNA, the strand uncoiled to its initial length within a few seconds. This recommended that the enzyme got nicked the supercoils, relieving stress and allowing the DNA to broaden to its prior length. But in the current presence of topotecan, the price of DNA uncoiling because of topoisomerase I was decreased twentyfold weighed against uncoiling without topotecan. However, the unexpected finding was that medication binding slowed topoisomerase I uncoiling of overwound DNA more than the rewinding of the strands of DNA that was underwound .Further research resulted in a cocktail of monoclonal antibodies that safeguarded 43 percent of monkeys when given as past due as five times after Ebola exposure, at the same time when the clinical signals of the condition are showing. The new research from Qui and co-workers at MAPP Biopharmaceutical Inc. Used ZMAPP to take care of monkeys provided a lethal dosage of Ebola. All the pets survived and didn’t show any proof the virus within their systems 21 times after infection, even after receiving the procedure 5 days after contamination. They also demonstrated that ZMAPP inhibits replication of the Ebola virus in cell lifestyle.